Metabolic reprogramming and circadian disruption drive cellular senescence. Discover how repurposing vutiglabridin to target ...

People who carry the APOE2 version of the apolipoprotein E gene are more likely to live to advanced age and are partly ...

Cellular senescence is a stress-responsive state of permanent cell-cycle arrest that contributes both to tissue repair and to the progression of age-related dysfunction. Although senescent cells no ...

Somewhere in Olmsted County, Minnesota, there are people who blew past their 100th birthday without ever developing heart ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, ...

Biological ageing is a highly heterogeneous process that cannot be captured by chronological age alone. Emerging evidence highlights the central role of ...

Cellular senescence has emerged as an important biological process in brain aging and neurodegeneration. Senescent cells are characterized by stable ...

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed. Aging cells secrete substances known to ...

Senescent CD8+ T cells impair CAR T therapy by reducing cell growth, migration, and tumor killing, with gene signatures ...

A urine test developed by scientists at the University of Cambridge has moved a step closer to clinical use following new ...